Syracuse is located at the gateway of Southeast Nebraska at the intersection of NE Highway 2 Expressway and NE Highway 50. We are 25 minutes from I-29 in Iowa and 40 minutes from I-80 in Nebraska. Syracuse is centrally located – just 25 miles southeast of Lincoln, NE; 50 miles south of Omaha, NE; 20 miles west of Nebraska City, NE; and 20 miles north of Tecumseh, NE.